Curriculum Vitae
I am biologist with a doctoral degree and I have a German background. I have extensive experience in human health and genetics, molecular biology, and cell biology. I am certified as a human geneticist. Since 2002 I am qualified as a Clinical genetic laboratory specialist (Fachhumangenetikerin).
Since 2009 I am a guest researcher in the group of Wim van der Putten, the department of Terrestrial Ecology at the NIOO in Heteren. At the University Wageningen I am mainly working on the development of media which contribute to the understanding of various scientific disciplines.
2008 -2010
♦ The main focus of my current work is scientific communication. To improve the communication between scientific disciplines and to develop useful tools and technologies.
♦ Lecturer for the EU-project IMAQUANIM, producing brochures Flyer and other text media which allow a better understanding of scientific research. Expertise to apply: In Design
♦ Docent for upgrading distant learning courses in Animal Sciences Expertise to apply: Camptasia, voice recording, interactive media PowerPoint, Adobe Photoshop.
2000-2008
I have worked as a scientist in a range of research institutes and companies in Germany to address a range of different questions. I have worked on the identification of human disease related chromosome abnormalities and have extended the range of diagnostic methods for non-invasive prenatal diagnostics in humans.
At the Heart Clinic, I established tests to control the biocompatibility of new implant materials for cardiovascular diseases. Additionally, I have experience to teach and to train technicians and students in the fields of biomedicine and cell biology. I have established courses for tissue culture techniques, mutations analysis, and DNA- fingerprinting as well as RNA-techniques. For my engagements and my efforts I have received the Business Award of German Land North Rhine-Westphalia in 2008.
Co-Operation
♦ German associations for technicians
♦ Deutscher Verband Technischer Assistentinnen/Assistenten in der Medizin e.V.
♦ Membership
♦ The German Society of Human Genetics (GfH)
♦ Vereniging Van Vrouwen Met Een Hogere Opleiding (VVAO)
Selected Publications
Publications (28 Articles)
2004-2010
A cis-regulatory site downregulates PTHLH in translocation t(8;12)(q13;11.2) and leads to Brachydactyly Type E.
Maass PG, Wirth J, Aydin A, Rump A, Stricker S, Tinschert S, Otero M, Tsuchimochi K, Goldring MB, Luft FC, Bähring S.
Hum Mol Genet. 2010 Mar 1;19(5):848-60.
Beruflicher Erfolg mit langfristiger Perspektive: Gewusst wie in der Zellkulturtechnik. Wirth J.
MTA-Dialog 5 (2009), Nr. 10, S. 24 – 26.
Zellkulturtechniken: Die verschiedenen Techniken für Zell- und Gewebekulturen als wichtigste Prüfmethoden in der Gesundheits- und Umweltmedizin. Wirth J.
Newsletter Quartal IV, 2008.
Die Polymerase-Ketten-Reaktion (PCR). Isolierung, Amplifizierung und Detektion von Nukleinsäuren. Newsletter der Technischen Assistenten in der Medizin. Wirth J. Newsletter Quartal II, 2007.
Mild phenotype in two unrelated patients with a partial deletion of 21q22.2-q22.3 defined by FISH and molecular studies.
Daniela Ehling, Ingo Kennerknecht, Annelore Junge, Bettina Prager, Rita Exeler, Beate Lemcke ,Juergen Horst, Thomas Schmitt-John, Oliver Bartsch, J Wirth.
Am J Med Genet 2004: 15;131(3):265-72.
Molecular cytogenetic analysis of a de novo balanced X;autosome translocation: Evidence for predominant inactivation of the derivative X chromosome in a girl with multiple malformations.
Glaeser B, Shirneshan K, Bink K, Wirth J, Kehrer-Sawatzki H, Bartz U, Zoll B, Bohlander SK.
Am J Med Genet 2004; 30;126(3):229-36.
Early onset, non-progressive, mild cerebellar ataxia co-segregating with a familial balanced translocation t(8;20)(p22;q13).
Hertz JM, Sivertsen B, Silahtaroglu A, Bugge M, Kalscheuer V, Weber A, Wirth J, Ropers HH, Tommerup N, Tumer Z.
J Med Genet 2004; 41(3):e25.
2002-2001
Constitutional de novo interstitial deletion of 8 Mb on chromosome 22q12.1-12.3 encompassing the neurofibromatosis type 2 (NF2) locus in a dysmorphic girl with severe malformations.
Barbi G, Rossier E, Vossbeck S, Hummler H, Lang D, Flock F, Terinde R, Wirth J, Vogel W, Kehrer-Sawatzki H.
J Med Genet 2002; 39(2):E6.
Clinical and molecular-cytogenetic studies in seven patients with ring chromosome 18.
Stankiewicz P, Brozek I, Helias-Rodzewicz Z, Wierzba J, Pilch J, Bocian E, Balcerska A, Wozniak A, Kardas I, Wirth J, Mazurczak T, Limon J.
Am J Med Genet 2001; 101(3) 226-39.
Microgeographic variation, habitat effects and individual signature cues in calls of chiffchaffs Phylloscopus collybita canarensis.
Naguib M, Hammerschmidt K, Wirth J.
Ethology 2001; 107 (4): 341-355.
Functional hemizygosity of PAFAH1B3 due to a PAFAH1B3-CLK2 fusion gene in a female with mental retardation, ataxia and atrophy of the brain.
Nothwang HG, Kim HG, Aoki J, Geisterfer M, Kubart S, Wegner RD, van Moers A, Ashworth LK, Haaf T, Bell J, Arai H, Tommerup N, Ropers HH, Wirth J.
Hum Mol Genet 2001; 10(8):797-806.
Molecular cytogenetic characterisation of a complex 46,XY,t(7;8;11;13) chromosome rearrangement in a patient with Moebius syndrome.
Borck G, Wirth J, Hardt T, Tonnies H, Brondum-Nielsen K, Bugge M, Tommerup N, Nothwang HG, Ropers HH, Haaf T.
J Med Genet 2001; 38(2):117-21.
A Girl with phenotypic abnormalities and a de novo, apparently balanced translocation 46,XX,t(5;10)(q35.2q11.2).
Zhu G, Gillessen-Kaesbach G, Wirth J, Passarge E, Bartsch O.
Am J Med Genet 2001; 98(4):317-9.
A translocation breakpoint cluster disrupts the newly defined 3' end of the SNURF-SNRPN transcription unit on chromosome 15.
Wirth J, Back E, Huttenhofer A, Nothwang HG, Lich C, Gross S, Menzel C, Schinzel A, Kioschis P, Tommerup N, Ropers HH, Horsthemke B, Buiting K.
Hum Mol Genet 2001; 10(3):201-10.
2000
Molecular cloning of Xp11 breakpoints in two unrelated mentally retarded females with X;autosome translocations.
Nothwang HG, Schroer A, van der Maarel S, Kubart S, Schneider S, Riesselmann L, Menzel C, Hinzmann B, Vogt D, Rosenthal A, Fryns J, Tommerup N, Haaf T, Ropers HH, Wirth J.
Cytogenet Cell Genet 2000; 90(1-2):126-33.
High resolution comparative genomic hybridisation analysis reveals imbalances in dyschromosomal patients with normal or apparently balanced conventional karyotypes.
Kirchhoff M, Rose H, Maahr J, Gerdes T, Bugge M, Tommerup N, Tumer Z, Lespinasse J, Jensen PK, Wirth J, Lundsteen C.
Eur J Hum Genet 2000; 8(9):661-8.
Molecular cloning of the critical region for glomerulopathy with fibronectin deposits (GFND) and evaluation of candidate genes.
Vollmer M, Kremer M, Ruf R, Miot S, Nothwang HG, Wirth J, Otto E, Krapf R, Hildebrandt F.
Genomics 2000; 68(2):127-35.
Molecular cytogenetic characterisation of partial trisomy 9q in a case with pyloric stenosis and a review.
Heller A, Seidel J, Hubler A, Starke H, Beensen V, Senger G, Rocchi M, Wirth J, Chudoba I, Claussen U, Liehr T.
J Med Genet 2000; 37(7):529-32.
DXS6673E encodes a predominantly nuclear protein, and its mouse ortholog DXHXS6673E is alternatively spliced in a developmental- and tissue-specific manner.
Scheer MP, van der Maarel S, Kubart S, Schulz A, Wirth J, Schweiger S, Ropers H, Nothwang HG.
Genomics 2000;63(1):123-32.
1994-1999
Partial monosomy 2p as the single chromosomal anomaly in a case of renal metanephric adenoma.
Stumm M, Koch A, Wieacker PF, Phillip C, Steinbach F, Allhoff EP, Buhtz P, Walter H, Tonnies H, Wirth J.
Cancer Genet Cytogenet 1999; 115(1):82-5.
Systematic characterisation of disease associated balanced chromosome rearrangements by FISH: cytogenetically and genetically anchored YACs identify microdeletions and candidate regions for mental retardation genes.
Wirth J, Nothwang HG, van der Maarel S, Menzel C, Borck G, Lopez-Pajares I, Brondum-Nielsen K, Tommerup N, Bugge M, Ropers HH, Haaf T.
J Med Genet 1999; 36(4):271-8.
Molecular cytogenetic detection of 9q34 breakpoints associated with nail patella syndrome. Silahtaroglu A, Hol FA, Jensen PK, Erdel M, Duba HC, Geurds MP, Knoers NV, Mariman EC, Tumer Z, Utermann G, Wirth J, Bugge M, Tommerup N.
Eur J Hum Genet 1999; 7(1):68-76.
Mouse Dac, a novel nuclear factor with homology to Drosophila dachshund shows a dynamic expression in the neural crest, the eye, the neocortex, and the limb bud.
Caubit X, Thangarajah R, Theil T, Wirth J, Nothwang HG, Ruther U, Krauss S.
Dev Dyn 1999;214(1):66-80.
Nail patella syndrome in a cytogenetically balanced t(9;17)(q34.1;q25) carrier.
Duba HC, Erdel M, Loffler J, Wirth J, Utermann B, Utermann G.
Eur J Hum Genet 1998; 6(1):75-9.
Not para-, not peri-, but centric inversion of chromosome 12.
Silahtaroglu AN, Hacihanefioglu S, Guven GS, Cenani A, Wirth J, Tommerup N, Tumer Z. J Med Genet 1998;35(8):682-4.
Identification of positional candidates for neurological disorders on chromsome 13q14-->q22.
Nothwang HG, Wirth J, Brandl B, Haaf T, Nielsen KB, Tommerup N, Ropers HH. Cytogenet Cell Genet 1997; 79(3-4):293-7.
Complex FISH probes for the subtelomeric regions of all human chromosomes:
comparative hybridization of CEPH YACs to chromosomes of the Old World monkey Presbytis cristata and great apes.
Kingsley K, Wirth J, van der Maarel S, Freier S, Ropers HH, Haaf T.
Cytogenet Cell Genet 1997; 78(1):12-9.
G. A somatic cell hybrid panel for distal 17q: GDIA1 maps to 17q25.3.
Wagner T, Tommerup N, Wirth J, Leffers H, Zimmer J, Back E, Weissenbach J, Scherer Cytogenet Cell Genet 1997; 76(3-4):172-5.
Translocation breakpoints in three patients with campomelic dysplasia and autosomal sex reversal map more than 130 kb from SOX9.
Wirth J, Wagner T, Meyer J, Pfeiffer RA, Tietze HU, Schempp W, Scherer G.
Hum Genet 1996; 97(2):186-93.
SOX20, a new member of the SOX gene family, is located on chromosome 17p13.
Meyer J, Wirth J, Held M, Schempp W, Scherer G.
Cytogenet Cell Genet 1996; 72(2-3):246-9.
Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9.
Wagner T, Wirth J, Meyer J, Zabel B, Held M, Zimmer J, Pasantes J, Bricarelli FD, Keutel J, Hustert E, et al.
Cell 1994; 79(6):1111-20.
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